Blocking IL-11 Improves Healthspan and Lifespan in Mice
Scientists Make Breakthrough in Anti-Aging Research
New Study Demonstrates Promising Results in Extending Lifespan
In a groundbreaking study, scientists have discovered that blocking the protein interleukin-11 (IL-11) can significantly improve healthspan and lifespan in mice.
Led by Anissa Widjaja and Stuart Cook, the researchers found that both genetic and pharmacological blockade of IL-11 had positive effects on the animals.
Key Findings:
- Genetic deletion of the IL11 gene extended the lifespan of mice by 249 days.
- Treatment with anti-IL-11 for 25 weeks in 75-week-old mice improved metabolism and muscle function.
- Administration of anti-IL-11 from 75 weeks of age until death extended the median lifespan of male mice by 225 days and female mice by 153 days.
These findings suggest that targeting IL-11 could be a promising therapeutic strategy for improving health outcomes and extending human lifespan.
Implications for Human Health
The study's implications for human health are significant, as IL-11 levels are known to increase with age and are associated with various age-related diseases, including obesity, type 2 diabetes, and Alzheimer's disease.
Further research is needed to determine whether blocking IL-11 in humans can yield similar benefits as observed in mice. However, the current study provides a promising foundation for future investigations into anti-aging therapies.
Source: Nature
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